Chondrocyte subtype

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August undefined, 2024

WebAug 1, 2024 · The chondrocyte is the unique resident cell of articular cartilage and thus solely responsible for ECM composition and regulation. Chondrocyte metabolism is influenced by its micro-environment, and in return influences ECM composition, organization and ultimately the mechanical resilience of cartilage 1, 2, 3. WebApr 10, 2024 · Autologous chondrocyte implantation (ACI) involves taking cartilage cells arthroscopically from a non-weight-bearing area of the knee: the cells are then cultured in a laboratory and multiplied, with the cells then being re-implanted into the chondral defect (Figure 1) in the knee 4–6 weeks later, most commonly as an open procedure.The …

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WebFeb 21, 2024 · Chondrocytes, which make up the majority of the cells in all samples, are further split into three empirically defined populations: cartilage progenitor cells (CPCs), fibrochondrocyte progenitors (FCPs), and homeostatic chondrocytes (HomCs), as well as four new populations known as C1–4 ( Figures 1D,F ). WebChondrocyte subtypes identified in mouse cartilage based on the expression of chondrocyte markers Col2a1, Acan, and Sox9 are shown in black oval. (D) Expression of chondrocyte markers Sox9... lbc nigel farage show today

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and …

WebJun 25, 2024 · Eight subtypes of P2Y family, namely P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, belong to the G protein-coupled receptors (GPCRs) family and regulate a variety of cellular processes, including proliferation, differentiation, secretion, cell adhesion, and migration. ... Chondrocyte migration enhancement therapy was also … WebJun 22, 2024 · Lawrence Livermore National Laboratory (LLNL) scientists have profiled articular cartilage from healthy and injured mouse knee joints at a single-cell resolution … WebNov 18, 2024 · Chondrocytes were seeded on the inner side of the membrane (inner bottom group) to prevent direct contact with host cells, while soluble factors were … lbc new student handbook

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte …

Single-cell rna seq analysis identifies the biomarkers and ...

WebNov 15, 2024 · Results: In this study, we characterized the single-cell expression profiling of 480 chondrocyte samples and found hypertrophic chondrocyte (HTC), homeostatic chondrocyte (HomC) and fibrocartilage chondrocyte (FC) respectively. The results of GO and KEGG analysis showed the candidate marker genes made specific function in these … WebSep 27, 2024 · The chondrocyte-like subpopulation is the predominant cell type and percentages of this subpopulation increase with disease severity. Despite … lbc no. 61 dated march 18 1996WebAs expected, all chondrocyte subtypes showed significant enrichment for the ontology terms 'cartilage development' and 'ECM organization' ( Figure 4 A). However, many of the cartilage ECM genes ... lbc nick and carol

"WebJun 10, 2024 · We identified six mouse chondrocyte subtypes with highly molecular fidelity to the human subtypes. This study allowed us to elucidate the full extent of … " - Chondrocyte subtype

Chondrocyte subtype

Chondrocyte secretome: a source of novel insights and …

WebMay 10, 2024 · Although studies have reported that three subtypes, including pre-hypertrophic chondrocytes, hypertrophic chondrocytes, and proliferative chondrocytes exist in the ... Prein et al., 2016), new … WebJul 2, 2024 · However, genes identified as potential mediators of chondrocyte phenotypes in OA that were exclusively expressed (in > 1%) by synoviocytes but not by any of the chondrocyte subtypes are indicated by red solid dots with arrows; among these were genes for several key pro-inflammatory cytokines implicated in the pathogenesis of OA, …

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WebCharacterization of chondrocyte subtypes. (A) Feature plots showing the expression of key chondrocyte markers. Blue: high expression, grey: low expression. (B) UMAP plots … WebJun 10, 2024 · Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Aimy Sebastian Lawrence Livermore National Laboratory, Physical and Life Science Directorate, Livermore, CA 94550, USA. Author profile Search articles by ORCID

WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. Notably, in the NP, a PROCR +... Metrics - Spatially defined single-cell transcriptional profiling characterizes ... WebNov 15, 2024 · Chondrocyte is the only cell type present in mature cartilage and is responsible for repairing damaged cartilage tissue [ 4 ]. Dysfunction of chondrocytes will result in degradation of the matrix, cell death and total loss of cartilage integrity [ 5 ].

WebJun 7, 2024 · X-PCI is able to resolve the three layers and the architectural organization of cartilage including changes in chondrocyte cell morphology, chondrocyte subgroup distribution and (re-)organization as well as its subtle matrix structures. ... the molecular and functional profiles of various chondrocyte subtypes and understanding the interplay ...

WebMechanical stress protects against chondrocyte pyroptosis through lipoxin A 4 via synovial macrophage M2 subtype polarization in an osteoarthritis model. Our previous study …

WebHypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (VEGF), receptor activator of nuclear factor kappa-B ligand (RANKL) and matrix metallopeptidases-9/13 (MMP-9/13). lbc now scheduleWebApr 4, 2024 · The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively … lb co2 to metric tonsWebJun 21, 2024 · Lawrence Livermore National Laboratory (LLNL) scientists have profiled articular cartilage from healthy and injured mouse knee joints at a single-cell resolution and identified nine chondrocyte subtypes … lbc new york to manilaWebIn vitro, CTS and LXA4both promoted M2 subtype polarization of synovial macrophages, which inhibited the nuclear translocation of NF-κB p65 and formation of NLRP3 in chondrocytes. In vivo, the OAE treatment exerted protective effects on articular cartilage and facilitated M2 polarization of synovial macrophages. lbc n-pack smallWebDec 22, 2024 · Results We identified and localized cell types in inner and outer meniscus and found new chondrocyte subtypes associated with degeneration. The observations suggested understandings on how ... lbc new zealandWebSeveral subpopulations, including effector chondrocytes (ECs), regulatory chondrocytes (RegCs), proliferative chondrocytes (ProCs) and hypertrophic chondrocytes (HTCs) were found in normal cartilage … lbc of greater yorkWebSubchondral insufficiency fracture of the knee (SIFK) is a common cause of knee joint pain that mainly afflicts the elderly. Until now, how a sudden insufficiency fracture of subchondral bone affects the transcriptomic profiles of cartilage in SIFK and OA patients are largely unknown. Methods lbc official customer care channels