WebAug 15, 2024 · CIS/TRANS isomers have different physical properties Although these two compounds are very similar, they have slightly different physical properties. Both are … WebThe present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of …
Perturbation of Iron Metabolism by Cisplatin through ... - PubMed
WebCisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a guanine baseon DNA. This property is fundamental to the mechanism of its ... Transplatin is a geometric stereoisomer of cisplatin and does not work as an anticancer drug. Explain why. WebDec 19, 2024 · Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression. ... R.G. GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplatin-mediated cytotoxicity to colon carcinoma HCT116 cells. Cancer Sci. 2012, 103, 1848–1856. [Google Scholar] Dou, N.; Chen, J.D.; … small town pastoralism
USP Monographs: Cisplatin - Pharmacopeia.cn
WebMar 1, 1998 · Cisplatin and transplatin [ cis - and trans -PtCl 2 (NH 3) 2 respectively], Pt 2 Cl 2 (Spym) 4 (Spym = 2-mercaptopyrimidine anion), Pd-famotidine and Pt-famotidine were incubated with DNA for 24 h at 37°C and then observed with an atomic force microscope. WebTransfer about 50 mg of Cisplatin, accurately weighed, to a 100-mL volumetric flask, and dilute with saline TS to volume. Completely dissolve by stirring by mechanical means for 30 minutes. Use within 4 hours. WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … highwood guitar parts