Clearance of theophylline is decreased by
WebCongestive Heart Failure (CHF) Theophylline clearance is decreased by 50% or more in patients with CHF. The extent of reduction in theophylline clearance in patients with CHF appears to be directly correlated to the … WebDosage Guidelines for Theophylline in Children Older Than 6 Months and Adults Who Have No Risk Factors for Decreased Theophylline Clearance. Transient effects similar to those of caffeine, such as ...
Clearance of theophylline is decreased by
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WebJun 27, 2024 · Chronic theophylline toxicity can occur when there is an accumulation of the drug due to metabolism being overwhelmed or inhibited. It can also occur when clearance is decreased. Toxicokinetics. Toxic doses of theophylline can be as low as 7.5 mg/kg. When taken orally, 80% to 100% of theophylline is absorbed in the … WebSep 21, 2024 · In patients with cardiac decompensation, cor pulmonale, older patients, or those on medications that are known to decrease …
WebJul 18, 2024 · Theophylline is metabolized in the liver and levels are sensitive to stimulation or inhibition of the P450 enzyme system and levels are increased by many drugs such as cimetidine, corticosteroids, … WebThe clearance of theophylline is decreased by an average of 30% in healthy elderly adults (>60 yrs) compared to healthy young adults. Theophylline clearance may be …
WebIn addition to bronchodilation, theophylline increases diaphragmatic contractility, increases mucociliary clearance, and exerts some antiinflammatory effects. Theophylline is a general central nervous system stimulant and specifically … WebAminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. ... and to neonates and the elderly, since in all of these circumstances theophylline clearance may be decreased, resulting in increases in serum-theophylline concentrations and serum half-life ...
The clearance of Theophylline is decreased by an average of 30% in healthy elderly adults (> 60 years) compared to healthy young adults. Careful attention to dose reduction and frequent monitoring of serum Theophylline concentrations are required in elderly patients (see WARNINGS). Pediatrics See more Theophylline is structurally classified as a methylxanthine. It occurs as a white, odorless, crystalline powder with a bitter taste. Anhydrous Theophylline has the chemical name 1H … See more Theophylline extended-release tablets are contraindicated in patients with a history of hypersensitivity to Theophylline or other components in the … See more Theophylline extended-release tablets are indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema … See more
WebFeb 10, 2024 · Decreased theophylline clearance and the resulting higher-than-predicted serum levels of the drug are caused by pneumonia; heart failure; infections; … chillaxification tour 2021WebNov 2, 1983 · The elimination of theophylline (clearance, half-life) was investigated in 50 patients with chronic congestive heart failure (grade III/IV) and in 20 controls. The cardiac diagnosis was based on clinical and hemodynamic parameters. Patients with congestion of the liver showed a significant reduction …. grace church of avondaleWebTheophylline metabolic clearance to 3-MX as well as to 1-MU decreased with increasing dose but clearance to DMU remained unnaffected by the size of dose. The individual Michaelis-Menten parameters Km and Vmax were estimated for six subjects receiving three different single doses. grace church of avondale jacksonville flWebTheophylline is a drug commonly used to treat asthma due to its anti-inflammatory and bronchodilatory properties. Testosterone (TES) has been suggested to reduce the severity of asthma symptoms.... grace church of arvada coloradograce church of arvadaWebIncreased risk of hyperkalemia when used concurrently with an ACEI or ARB in presence of decreased creatinine clearance. Use with caution in patients on ACEI or ARB and decreased creatinine clearance. Low Strong. ... Theophylline. Cimetidine. Increased risk of theophyllinetoxicity. Avoid. Moderate. Strong. Theophylline. Cipro. floxacin ... grace church of all nations liveWebIn addition to the factors listed above, theophylline clearance is increased and half-life decreased by low carbohydrate/high protein diets, parenteral nutrition, and daily consumption of charcoal-broiled beef. A high carbohydrate/low protein diet can decrease the clearance and prolong the half-life of theophylline. Page 3 of 20 grace church ofallon mo