Ctgf target
WebMar 23, 2024 · As shown in Figure S3C, overexpression of NFATC2 significantly upregulated the expression levels of the target genes of Hippo/YAP signaling pathway (CTGF and Gli2) 18–20 in both HCT-116 and HT-29 cells. Conversely, reduced mRNA expression levels of CTGF and Gli2 were observed in NFATC2-knockdown HCT-116 … WebAntibodies that detect CTGF can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and …
Ctgf target
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WebThe multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the HSPG (proteoglycan) and low … WebSep 11, 2024 · Although the YAP target CTGF was decreased after Ras transformation in MCF10A cells, increased expression is seen after HRas G12V expression in HEK293T cells 25.
WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast …
WebOct 5, 2024 · CTGF may be a novel target for BPD therapy in preterm infants. Introduction. Bronchopulmonary dysplasia (BPD) was first described by Northway in 1967 (Northway et al., 1967). Although more than 50 years have passed and the survival rates of premature infants have increased, BPD is still a major complication in these infants (Jain and … WebSep 6, 2024 · Our previous studies showed that Cx43 was a downstream target protein of CTGF in chondrocytes that regulated cell-to-cell communication [27, 31]. Simultaneously, cementocytes specifically express Cx43 as a gap junction carrier to facilitate intercellular communication . Therefore, we speculated that Cx43 regulated by CTGF was involved in …
WebAug 28, 2024 · In association with positive and negative transcription factors, Smads regulate a wide spectrum of target genes . ... -derived sol-Eng. sol-Eng was detected in lysates of HepG2 cells and its presence reduces the expression of the TGF-β1 target protein CTGF at all-time points analysed. In order to test if sol-Eng can bind ligand, we …
WebCTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates the deposition of ECM components, including collagen. However, unlike TGF-β, CTGF does not exert any effect on epidermal or inflammatory cells. Thus, CTGF appears to specifically influence ECM deposition at the ... chuck ren mystic warrior printSeveral clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and pancreatic cancer. CTGF (CCN2) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, the von … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. … See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more desktop backgrounds for marchWebCTGF/CCN2: Products. CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGF … desktop backgrounds for large monitorsWebCTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates the deposition of ECM components, including … desktop backgrounds for productivityWebHere, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further … desktop backgrounds for double screenWebMar 10, 2024 · Overall, our work suggests a novel function for CTGF as a modulator of cancer metabolism, indicating that CTGF is a potential therapeutic target in TNBC. … desktop backgrounds for large screenWebOct 14, 2014 · CTGF is a therapeutic target for metastatic melanoma. Oncogene 33, 1093–1100 (2014). CAS PubMed Google Scholar Neesse, A. et al. CTGF antagonism … desktop backgrounds for macbook pro