High grafix

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August undefined, 2024

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GraFix: stabilization of fragile macromolecular complexes for …

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High grafix

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WebHere, we review the GraFix (Gradient Fixation) method to purify and stabilize macromolecular complexes for single particle cryo-electron microscopy (cryo-EM). During GraFix, macromolecules undergo a weak, intramolecular chemical cross-linking while being purified by density gradient ultracentrifugat …

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