Webb1 mars 2024 · histone lactylation Warburg effect lactate macrophage polarization Cellular metabolism consists of the uptake and utilization of diverse nutrients in the environment … Webb17 feb. 2024 · However, its non-metabolic functions in physiol. and disease remain unknown. Here we show that lactate-derived lactylation of histone lysine residues …

Metabolic regulation of gene expression by histone lactylation

Webb7 juni 2024 · Histone lysine acylations are responsible for the regulation of gene transcription which are involved in the crosstalk between metabolism and epigenetics 1, … Webb27 juni 2024 · Lactate has recently been discovered to modify lysine residues on histones, a post-translational modification called lysine lactylation (Kla or Klac) 3. Cellular stress … peer reviewed articles on phonemic awareness

What Is Histone Acetylation? Sciencing

Webb26 okt. 2024 · Moreover, macrophages that could not produce lactate could increase the expression of inflammatory genes in response to stimulation with LPS, but could not … Webb16 mars 2024 · Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage … WebbHistone Lactylation: A New Role for Glucose Metabolism Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study … measuring glass with lid