WebFeb 23, 2024 · These data show that palbociclib treatment increases the sensitivity to lenalidomide and pomalidomide in multiple myeloma cells. In contrast, combined treatment of palbociclib and melphalan,... WebOct 1, 2024 · Palbociclib is a weak base with a pH-dependent solubility. • Breast cancer patients treated with palbociclib and PPIs have significantly shorter PFS. • Drug-drug …
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WebSep 9, 2024 · Palbociclib is a weak base with pH-dependent solubility and potential drug-drug interaction at the absorption level may affect clinical pharmacokinetics. The current study was aimed at investigating the effect of co-administration of PPIs and palbociclib on progression-free survival (PFS) in metastatic breast cancer (mBC) patients. WebPalbociclib is a yellow to orange powder with a pKa of 7.4 (secondary piperazine nitrogen) and 3.9 (pyridine nitrogen). The solubility of palbociclib in aqueous media decreases over the range pH 4.3 to pH 9.0from great er than 0.7 mg/mL to less than 0.002 mg/mL. At or below pH 4, palbociclib behaves like a high-solubility compound. WebFeb 3, 2024 · Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the … taiwan game devotion