Pin1 activity
WebExtending these findings, in this study we have demonstrated that Pin1 activity can control the association of RNAP II with active genes throughout the cell cycle, by modulating CTD … WebAug 2, 2024 · For the NPA-bound PIN1 cryo-EM sample preparation, purified PIN1 was first incubated with NPA (Sigma) at a final concentration of 100 μM at room temperature for …
Pin1 activity
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WebPin1 consists of two domains: a N-terminal phosphor-peptide binding domain (WW domain) and a C-terminal catalytic domain (PPIase domain) (Figure 1A) [].Pin1 functions rely on interdomain communication; an isolated PPIase domain construct retains isomerase activity comparable to or greater than that of full-length Pin1, but full-length Pin1 shows different … WebOur research has focused on the regulation of Pin1 activity during the maintenance of healthy neuronal spines, hopefully giving insight on some of the early events of …
PIN1 has been widely investigated as an interesting molecular target for the inhibition of cancer cell lines, such as breast, cervical, ovarian, and endometrial cancers. Studies have demonstrated that all-trans retinoic acid (ATRA), a natural compound derivative from Vitamin A is involved with PIN1 inhibition. … See more Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine … See more The gene encoding Pin1 was identified in 1996 as a result of a genetic/biochemical screen for proteins involved in mitotic regulation. It was found to be essential for cell division in … See more Pin1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 … See more • Lu KP, Liou YC, Zhou XZ (Apr 2002). "Pinning down proline-directed phosphorylation signaling". Trends in Cell Biology. 12 (4): … See more Phosphorylation of Ser/Thr-Pro motifs in substrates is required for recognition by Pin1. Pin is a small protein at 18 kDa and does not have a nuclear localization or export signal. … See more PIN1 has been shown to interact with: • C-jun, • CDC25C, • CDC27, • CSNK2A2, • Casein kinase 2, alpha 1, See more • Overview of all the structural information available in the PDB for UniProt: Q13526 (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) at the PDBe-KB. See more WebThe first identified compound that inhibits PIN1 activity is juglone. Juglone has been demonstrated to inhibit PIN1 activity and suppress cell proliferation in various types of cancers including glioblastoma, HCC, and prostate cancer (Lee et al., 2009; Kanaoka et al., 2015; Wang et al., 2024).
WebWe found that normal vascular patterning was restored upon PIN1:GFP expression in the epidermis of pin1 mutants (Table 1 and Fig. S2 F–J). The development of vasculature in the absence of PIN1 activity in internal tissue layers of the leaf may reflect the compensatory action of other PIN protein family members acting redundantly in these tissues. WebMar 27, 2024 · Pin1 was discovered through a yeast two-hybrid screen designed to identify proteins that interact with NIMA, an essential mitotic kinase in Aspergillus nidulans(Lu et al., 1996). It belongs to PPIases, which comprise three structurally distinct subfamilies: the cyclophilins, the FK506-binding proteins (FKBPs), and the parvulins (Galat, 2003).
WebMar 27, 2024 · Pin1 was discovered through a yeast two-hybrid screen designed to identify proteins that interact with NIMA, an essential mitotic kinase in Aspergillus nidulans(Lu et …
WebJun 21, 2012 · PIN1 and DR5 are strongly expressed at the location of future organ development (Reinhardt et al., 2003; Heisler et al., 2005; Bayer et al., 2009), and the inhibition of PIN1 activity in Arabidopsis either by genetic means or through the use of the auxin polar transport inhibitor N-(1-naphthyl) phthalamic acid results in the formation of naked ... jd9 brakesWebExtending these findings, in this study we have demonstrated that Pin1 activity can control the association of RNAP II with active genes throughout the cell cycle, by modulating CTD phosphorylation. Pin1 can also influence the nuclear distribution of RNAP II, as Pin1-overexpression caused RNAP II to accumulate in enlarged speckle-associated ... jd 85g excavatorWebPin1 consists of two domains: a N-terminal phosphor-peptide binding domain (WW domain) and a C-terminal catalytic domain (PPIase domain) (Figure 1A) [].Pin1 functions rely on … jd 825i gatorWebJul 1, 2013 · The Pin1 prolyl isomerase regulates phosphorylation signaling by controlling protein conformation after phosphorylation, and its upregulation promotes oncogenesis via acting on numerous oncogenic molecules. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activit … jda-22u/60109004WebFeb 13, 2024 · Pin1 consists of short N-terminal protein-protein interaction domain that allows enzyme to bind phosphoproteins and longer C … kyteman zangerWebMar 9, 2024 · Pin1 functions as a novel player in GnRH-induced signal pathways and is involved in gonadotropin beta-subunit gene transcription by modulating the activity of … jda-14u/60109005WebMar 17, 2024 · PIN1 can interact with YAP/TAZ in a phosphorylation-independent manner and WW domain of PIN1 is necessary for this interaction (Khanal et al., 2024). PIN 1 also plays a critical role in the nuclear translocation of TAZ contributes to the dysregulation of Hippo signaling, leading to oncogenic signaling (Khanal et al., 2024; Kim et al., 2024). kyte mcdonald baseball